Professor Gary Entrican
Moredun Research Institute
Pentlands Science Park
Midlothian EH26 0PZ
Gary Entrican is a Principal Research Scientist at Moredun and Honorary Professor in the College of Medicine and Veterinary Medicine, University of Edinburgh. He graduated with BSc Hons in Immunology from University of Glasgow, where he also conducted his PhD in Immunology. He joined Moredun in 1986 working on immune regulation in sheep and has applied his immunological skills to studies on causes of infectious abortion in sheep, initially on Border Disease Virus and more recently on Chlamydia abortus.
His immunological skills are in the areas of ruminant cellular immunology, cytokine biology and the understanding of host-pathogen interactions during infection. The ultimate aim of his research is to identify immunological correlates of protection that underpin vaccine design. He has established competitively-funded research links with colleagues at University of Edinburgh and currently leads a BBSRC-funded Industrial Partnership Award on identification of immune correlates in sheep and cattle with the Roslin Institute/University of Edinburgh and AbD Serotec.
He is a Core member of BBSRC Committee A and is Chair of the International Veterinary Immunology Committee Toolkit, a global committee that advances the development and exchange of immunological reagents for veterinary species. He is also a member of the Advisory Board of the Veterinary Immunology Reagent Network, a project funded by the United States Department of Agriculture to develop immunological tools to improve animal health, welfare and productivity.
- Investigation of the innate and adaptive immune responses to C. abortus infection in sheep (RERAD Programme Research, 2006-11).
- Development and characterization of immunological tools and technologies that underpin disease research in sheep (Moredun Immunology Theme, RERAD Programme Research, 2006-11).
- Aberrant prokinectin expression as a cause for ectopic pregnancy: the effect of Chlamydia trachomatis and smoking. In collaboration with Professors Andrew Horne (UoE), Hilary Critchley (UoE) and Henry Jabbour (MRC) (Wellbeing of Women, 2008-2010).
- The Network for Animal Disease Infectiology Research Facilities (NADIR) in collaboration with Dr Keith Ballingall (Moredun). A multicentre European Consortium to provide access to facilities and training opportunities for animal disease research (European Commission, 2008-2012).
Selected Key Publications
- Entrican, G., & Wheelhouse N. M. 2006. Immunity in the female sheep reproductive tract. Veterinary Research. 37(3):295 - 309.
- Wattegedera, S. R., Rocchi M., Sales J., Howard C., Hope J., & Entrican G. 2008. Antigen-specific peripheral immune responses are unaltered during normal pregnancy in sheep. Journal of Reproductive Immunology. 77(2):171 - 178.
- Wheelhouse, N. M., Wattegedera S. R., Fleming D., Fitch P., Kelly R., & Entrican G. 2008. Chlamydia trachomatis and Chlamydophila abortus induce the expression of secretory leukocyte protease inhibitor in cells of the human female reproductive tract. Microbiology and Immunology. 52(9):465 - 468.
- Entrican, G., Lunney J. K., Rutten V. P., & Baldwin C. L. 2009. A current perspective on availability of tools, resources and networks for veterinary immunology. Veterinary Immunology and Immunopathology. 128(1-3):24 - 29.
- Rocchi, M., Wattegedera S. R., Meridiani I., & Entrican G. 2009. Protective adaptive immunity to Chlamydophila abortus infection and control of ovine enzootic abortion (OEA). Veterinary Microbiology. 135(1-2):112 - 121.
- Entrican, G., Wattegedera S. R., Rocchi M., & Wheelhouse N. 2009. Pregnancy, indoleamine 2,3-dioxygenase (IDO) and chlamydial abortion: An unresolved paradox. Veterinary Microbiology. 135(1-2):98 - 102.
- Wheelhouse, N., Wattegedera S. R., Stanton J., Maley S. W., Watson D., Jepson C., et al. 2009. Ovine trophoblast is a primary source of TNFα during Chlamydophila abortus infection. Journal of Reproductive Immunology. 80(1-2):49 - 56.
- Shaw, J. L. V., Denison F. C., Evans J., Durno K., Williams A. R., Entrican G., et al. 2010. Evidence of prokineticin dysregulation in Fallopian tube from women with ectopic pregnancy. Fertility and Sterility. (In Press):.
- Wattegedera, S. R., Watson D. M., Hope J. C., Kaiser P., Sales J., McInnes C. J., et al. 2010. Relative quantitative kinetics of interferon-gamma and interleukin-10 mRNA and protein production by activated ovine peripheral blood mononuclear cells. Veterinary Immunology and Immunopathology. 136(1-2):34-42.
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