Professor Gary Entrican
Address:
Moredun Research Institute
Pentlands Science Park
Bush Loan
Penicuik
Midlothian EH26 0PZ
Scotland
Telephone Number:
+44 (0)131 445 5111
Email address:
Gary Entrican is the Immunology Theme Leader at Moredun and Honorary Professor at The Roslin Institute, University of Edinburgh. He graduated with BSc Hons in Immunology from University of Glasgow, where he also conducted his PhD in Immunology. Gary joined Moredun in 1986 and has worked mainly on infectious causes of abortion in sheep, most notably Border Disease Virus and Chlamydophila abortus.
His immunological skills are in the areas of ruminant cellular immunology, cytokine biology and the understanding of host-pathogen interactions during infection. The ultimate aim is to identify immunological correlates of disease and correlates of protection that inform on novel vaccine design and delivery systems. He has established competitively-funded research links with colleagues at University of Edinburgh in the Centre for Inflammation Research and in Reproductive Biology.
He is Co-Chair of IUIS-VIC Toolkit, an international committee that aims to advance the development and exchange of immunological reagents for veterinary species, and a member of the Advisory Board of USDA Veterinary Immunology Reagent Network.
Current Research:
- Investigation of the innate and adaptive immune responses to C. abortus infection in sheep (RERAD Programme Research, 2006-11).
- Development and characterization of immunological tools and technologies that underpin disease research in sheep (Moredun Immunology Theme, RERAD Programme Research, 2006-11).
- Aberrant prokinectin expression as a cause for ectopic pregnancy: the effect of Chlamydia trachomatis and smoking. In collaboration with Professors Andrew Horne (UoE), Hilary Critchley (UoE) and Henry Jabbour (MRC) (Wellbeing of Women, 2008-2010).
- The Network for Animal Disease Infectiology Research Facilities (NADIR) in collaboration with Dr Keith Ballingall (Moredun). A multicentre European Consortium to provide access to facilities and training opportunities for animal disease research (European Commission, 2008-2012).
Selected Key Publications:
Selected Key Publications
- Entrican, G., & Wheelhouse N. M. 2006. Immunity in the female sheep reproductive tract. Veterinary Research. 37(3):295 - 309.
- Wattegedera, S. R., Rocchi M. S., Sales J., Howard C., Hope J., & Entrican G. 2008. Antigen-specific peripheral immune responses are unaltered during normal pregnancy in sheep. Journal of Reproductive Immunology. 77(2):171 - 178.
- Wheelhouse, N. M., Wattegedera S. R., Fleming D., Fitch P., Kelly R., & Entrican G. 2008. Chlamydia trachomatis and Chlamydophila abortus induce the expression of secretory leukocyte protease inhibitor in cells of the human female reproductive tract. Microbiology and Immunology. 52(9):465 - 468.
- Entrican, G., Lunney J. K., Rutten V. P., & Baldwin C. L. 2009. A current perspective on availability of tools, resources and networks for veterinary immunology. Veterinary Immunology and Immunopathology. 128(1-3):24 - 29.
- Rocchi, M. S., Wattegedera S. R., Meridiani I., & Entrican G. 2009. Protective adaptive immunity to Chlamydophila abortus infection and control of ovine enzootic abortion (OEA). Veterinary Microbiology. 135(1-2):112 - 121.
- Entrican, G., Wattegedera S. R., Rocchi M. S., & Wheelhouse N. 2009. Pregnancy, indoleamine 2,3-dioxygenase (IDO) and chlamydial abortion: An unresolved paradox. Veterinary Microbiology. 135(1-2):98 - 102.
- King, A. E., Wheelhouse N., Cameron S., McDonald S. E., Lee K. - F., Entrican G., et al. 2008. Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection. Human Reproduction. 24(3):679 - 686.
- Wheelhouse, N., Wattegedera S. R., Stanton J., Maley S. W., Watson D., Jepson C., et al. 2009. Ovine trophoblast is a primary source of TNFα during Chlamydophila abortus infection. Journal of Reproductive Immunology. 80(1-2):49 - 56.
- Shaw, J. L. V., Denison F. C., Evans J., Durno K., Williams A. R., Entrican G., et al. 2010. Evidence of prokineticin dysregulation in Fallopian tube from women with ectopic pregnancy. Fertility and Sterility. (In Press):.
- Wattegedera, S. R., Watson D. M., Hope J. C., Kaiser P., Sales J., McInnes C. J., et al. 2010. Relative quantitative kinetics of interferon-gamma and interleukin-10 mRNA and protein production by activated ovine peripheral blood mononuclear cells. Veterinary Immunology and Immunopathology. 136(1-2):34-42.