Bacteriology
Current Projects | Reports | Posters
Bacterial diseases continue to have a major impact on the health and welfare of farm livestock. These diseases can be long standing problems that have never been properly controlled such as Johne's disease (Mycobacterium avium paratuberculosis) and enzootic abortion of ewes (Chlamydophila abortus), or emerging diseases such as pasteurellosis due to Pasteurella multocida, and Caseous lymphadenitis (Corynebacterium pseudotuberculosis). In both situations their future control will depend on intensive research into the molecular mechanisms of how these pathogens induce disease and how the host responds to infection.
The Bacteriology Division has two programmes of work; molecular pathogenesis and host bacterial interactions. In both of these programmes generic approaches to bacterial diseases are being developed with projects sharing techniques, reagents, equipment and staff. The advent of genomics and the wider availability of bacterial genome sequences has inevitably demanded different approaches to bacteriological research and the Division's scientists have already accessed the Functional Genomics Unit facility for such things as 2-D gel electrophoresis and mass spectrometric analyses of bacterial proteins.
Current Projects
- MRI Mycobacteria
Pulsed-Field Gel Electrophoresis Database
Principal contact: Dr Karen Stevenson - Contagious bovine pleuropneumonia (CBPP)
Principal contact: Dr Christian Schnier - Towards optimising dosage
ad minimising drug resistance for veterinary anti-infective chemotherapeutics
Principal contact: Dr Doug Jones (SEERAD core funded project) - Immune regulation during
pregnancy and control of Chlamydophila abortus
Principal contact: Dr Gary Entrican (SEERAD core funded project) - Proteomic approaches for
monitoring protein expression in bacterial pathogens
Principal contact: Dr David G E Smith (SEERAD core funded project) - Controlling ovine
chlamydial abortion
Principal contact: Dr David Longbottom (SEERAD core funded project) - Host pathogen interactions
and novel vaccination strategies in bovids infected with Pasteurella
multocida
Principal contact: Dr Chris Hodgson (SEERAD core funded project) - Pathogenesis of Mycobacterium
avium subspecies Paratuberculosis infection
Principal contact: Dr Karen Stevenson (SEERAD core funded project) - Improvement of diagnostic
and immunological control measures for bacterial respiratory pathogens
Principal contact: Professor Willie Donachie (SEERAD core funded project) - Comparative Bacterial Proteomics
Principal contact: Professor David G E Smith (SEERAD core funded project) - DNA vaccination as
a tool for understanding the pathogenesis of infectious bacterial
disease and controlling bacterial infections of ruminants
Principal contact: Dr David Longbottom (SEERAD flexible funded project) - Identification and
analysis of differences between IS901+ Mycobacterium avium
and Mycobacterium avium subspecies Paratuberculosis
Principal contact: Dr Karen Stevenson (SEERAD flexible funded project) - The immunological toolbox
Principal contact: Dr Gary Entrican (SEERAD collaborative flexible funded project) - Epithelial Barriers
as systems on Innate defence against infection
Principal contact: Dr Gary Entrican (SEERAD collaborative flexible funded project) - Diagnosis and control
of caseous lymphadenitis in sheep
Principal contact: Professor Willie Donachie (SEERAD collaborative flexible funded project) - Secretomes of bacterial
Foodbourne pathogens and functional asessment during interaction
with intestinal epithelium
Principal contact: Dr David G E Smith (SEERAD collaborative flexible funded project) - Elucidation of Regularly
and signalling networks that control bacterial disease development
Principal contact: Dr Chris Hodgson (SEERAD collaborative flexible funded project) - The role of wildlife
in the epidemiology of Mycobacterium avium subspecies Paratuberculosis
in domestic animals in Europe
Principal contact: Dr Karen Stevenson (EU funded project) - An HPLC and MS analysis of the
urines of autistic and control children
Principal contact: Dr John March (CSO funded project)
Reports
- Johne's Disease: improved control strategies in sight (Dr Karen Stevenson)
- E. coli 0157:H7 and other foodborne zoonoses (Prof. David GE Smith )
- "DNA Vaccines: the future for immunisation?" (Dr John March and Jason Clark)
- "CLA: research leads to diagnostic test" ( Prof. Willie Donachie and Dr Michael Fontaine)
- "Chlamydial Vaccine Development" (written by Dr David Longbottom)
- "Pasteurella multocida: Global Pathogen" (written by Dr Chris Hodgson)
- "Improving control options for ovine enzootic abortion" (written by Dr Gary Entrican)
- "Host innate immune response to bacterial lung infection" (written by Dr Chris Hodgson)
- "The Role Of Wildlife In The Epidemiology Of Paratuberculosis" (written by Dr Mike Sharp and Dr Karen Stevenson)
Posters
- Listing of posters has been moved to the Virtual Poster Room